Investigating the potential of dietary iron supplementation to enhance long-chain polyunsaturated fatty acid biosynthesis in Hediste diversicolor.

ABSTRACT: Fatty acyl desaturases are nutritionally regulated and depend on iron (Fe) for optimal activity. We hypothesised that dietary Fe supplementation, under conditions promoting desaturase upregulation, can enhance desaturase activity and improve n-3 LC-PUFA biosynthesis in invertebrates. The present study aimed to evaluate the effects of dietary Fe supplementation on LC-PUFA biosynthesis in H. diversicolor, a commercially important polychaete, using both In vitro and in vivo approaches. The in vitro assays revealed that Fe supplementation, from both inorganic (FeSO₄) and organic (ProPath^® Fe) sources, has potential to increase desaturase activity, particularly on the H. diversicolor methyl-end desaturase ωx2, under high-expression conditions simulated in yeast. In contras

SUBMITTER: Villena-Rodriguez A 

PROVIDER: S-EPMC12660862 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature