The additive effect of hemoglobin glycation index and glycemic variability to predict mortality in cardiac intensive care patients with and without diabetes.

ABSTRACT: The hemoglobin glycation index (HGI) and glycemic variability (GV) are important metabolic markers associated with cardiovascular diseases and their prognoses. However, the potential additive effect of these biomarkers on mortality risk remains unclear. This study aimed to investigate the independent and combined effects of HGI and GV on mortality in cardiac ICU patients, both with and without diabetes. We conducted a retrospective cohort analysis of 1636 individuals admitted to the cardiac ICU. The primary outcome was 28-day mortality, with 365-day mortality as a secondary endpoint. Kaplan-Meier survival curves, Cox proportional hazards models, restricted cubic splines, receiver operating characteristic (ROC) curve, and subgroup analyses were used to evaluate the relationship between the

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12660922 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature