Tissue residue depletion of cannabinoids in cattle administered industrial hemp inflorescence.

ABSTRACT: Despite interest in using industrial hemp (IH) in cattle feed, there are minimal safety data on tissues from exposed cattle. This study sought to describe cannabinoid tissue concentrations, estimate withdrawal times for cattle exposed to IH inflorescence, and generate human exposure estimates for Δ9-tetrahydrocannabinol and cannabidiol. Twenty male Holsteins received IH inflorescence orally at 4.2 mg/kg/d cannabidiolic acid for 14 d. Liver, kidney, muscle, and adipose were collected at 1, 2, 3, 5, and 8 days after IH administration and analyzed for cannabinoids using liquid chromatography mass spectrometry. Withdrawal intervals and target tissues were selected based on the slowest-depleting cannabinoid. ∆9-tetrahydrocannabinol was detected in liver, kidney, and adipose and cannabidiol in a

SUBMITTER: Fritz BR 

PROVIDER: S-EPMC12660957 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature