Exercise attenuates hepatic ectopic lipid deposition in high fat-diet rats via PKA-mediated phosphorylation of Perilipin5.

ABSTRACT: The lipid droplet-associated protein Perilipin5 exerts a dual regulatory function in hepatic lipid accumulation and lipolysis, positioning it as a critical target for non-alcoholic fatty liver disease (NAFLD) therapeutics. Given the well-established benefits of exercise in mitigating NAFLD, elucidating the role of Perilipin5 in this process is essential for understanding exercise-induced metabolic adaptations Twenty-four SD rats were randomly assigned to standard diet, high-fat diet, or high-fat diet plus treadmill exercise groups for six weeks. Assessments included body weight, blood glucose, serum lipid profiles, liver histology, hepatic lipid content, and biomarkers of liver injury. Additionally, lipolytic protein expression and the co-localization of Perilipin5 and CGI-58 were analyzed

SUBMITTER: Dong S 

PROVIDER: S-EPMC12661005 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature