The influence of CHRNA5 and D398N missense variation on social and emotional behaviors in rodents and humans.

ABSTRACT: Social behavior alterations, notably aggressivity-related behavioral states (ARBS), and substance use disorders (SUDs) show consistent associations. In psychopathology, ARBS and SUDs cluster together as externalizing disorders, which show evidence for shared genetic liability and are associated with emotional dysregulation. Human studies have identified a single nucleotide polymorphism (rs16969968) of CHRNA5 encoding the α5 subunit of nicotinic acetylcholine receptors (nAChRs) (hereafter called α5SNP) in association with nicotine dependence. The influence of α5 containing nAChRs (α5*nAChRs) and α5SNP on social behavior, ARBS and emotional regulation, promising endophenotypes for SUDs, remain to be characterized. We investigated dyadic and higher-level group social interactions, notably in

SUBMITTER: de Chaumont F 

PROVIDER: S-EPMC12661019 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature