Acute radiotoxicity studies and safety assessment of ¹⁶⁶Ho-EDTMP and ¹⁶⁶Ho-DOTMP for the palliative treatment of bone metastases.

ABSTRACT: Comprehensive studies on the acute toxicity and safety profiles of therapeutic doses of ¹⁶⁶Ho-EDTMP and ¹⁶⁶Ho-DOTMP in the bone tissue and bone marrow of animals are limited, particularly when ¹⁶⁶Ho produced in low-power reactors is used. These bone-specific complexes were synthesized through the coordination of ¹⁶⁶Ho³⁺ ions in a neutral buffer. Acute toxicity studies were conducted at a dose of 1850 MBq/kg over 14 days, whereas safety assessments were performed at therapeutic doses of 18.5, 37, and 74 MBq/kg over 30 days in ICR mice. Hematological, biochemical, and histopathological toxicities were evaluated. ¹⁶⁶Ho was obtained with high specific activities and radionuclide purity. These radiolabeled ligands were prepared w

SUBMITTER: Dang HHQ 

PROVIDER: S-EPMC12661045 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature