Quercetin hybrid-hydrogel microparticles modulate gut microbiota and improve memory in an antibiotic-induced dysbiosis rat model.

ABSTRACT: Gut microbiota plays a pivotal role in maintaining human health and well-being. Antibiotic-induced dysbiosis disrupts microbial balance and diversity leading to compromised physiological functions and adverse health outcomes. The present study investigates the functional potential of a dietary fiber-based hybrid-hydrogel microparticles formulation of the naturally occurring dietary flavonoid, quercetin (FQ-35), as a prebiotic intervention to restore gut and brain health through modulation of microbiome-gut-brain axis. An antibiotic cocktail was administered to induce gut microbial imbalance, and subsequently assessed the effects of supplementation of FQ-35 (100 mg/kg b.wt, for 14 days) on cognitive performance, gut microbiota, markers of gut and brain integrity, along with histopathologica

SUBMITTER: Parappilly SJ 

PROVIDER: S-EPMC12661057 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature