Atopic Multimorbidity in Adults With a Focus on Sensitization Patterns and T Cell Activation.

ABSTRACT:

Background

Atopic diseases-including atopic dermatitis (AD), asthma (AA), and allergic rhinitis (AR)-are driven by Th2 inflammation and often occur together (atopic multimorbidity), along with non-atopic comorbidities. Chronic spontaneous urticaria (CSU) is an autoimmune mast cell-driven disease, but its relationship to classic atopic diseases remains unclear. This study investigated the association of CSU with classical atopic diseases as well as sensitization patterns and T cell activation in atopic multimorbidity.

Methods

We conducted a prospective, single-center study involving 123 participants who completed structured questionnaires regarding physician-diagnosed AD, AA, AR, and/or CSU, as well as non-atopic comorbidities and a history of type I sensitizations. AD patien

SUBMITTER: Bialas A 

PROVIDER: S-EPMC12661119 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature