Milk Ladder Efficacy and Safety in IgE-Mediated Cow's Milk Allergy: A Systematic Review and Meta-Analysis of Controlled Studies.

ABSTRACT:

Background

Milk ladder (ML) is considered a potential therapeutic option for managing cow's milk allergy (CMA). Although the ML was initially developed to reintroduce cow's milk into the diet for individuals with non-IgE mediated CMA, it has also recently been used in IgE-mediated CMA.

Objective

To perform a systematic review and meta-analysis of the safety and efficacy of ML in children with IgE-mediated milk allergy.

Methods

We conducted a systematic literature review and meta-analysis of controlled studies in accordance with PRISMA guidelines. ML safety and ML efficacy compared to a strict avoidance diet and oral immunotherapy in children with IgE mediated CMA was evaluated. Meta-analysis was performed where ≥ 3 studies reported data. Methodological quality and ris

SUBMITTER: Cuomo B 

PROVIDER: S-EPMC12661123 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature