Exploring the potential of <i>Schmidtea mediterranea</i> as a model for reproductive toxicity through analysis of sterility caused defective m⁶A RNA regulation.

ABSTRACT: Development of alternative methods for analysis of reproductive toxicity is a challenge that requires the characterization of mechanistic endpoints linked to the toxicity. N ⁶-methyladenosine (m⁶A) is one of the most prevalent post-transcriptional modifications of eukaryotic RNA molecules and one that supports development of gametes in mammals. While the role of m⁶A RNA regulation in the soma of planarian flatworms has been previously studied, the presence and biological relevance of this regulatory pathway in the germline of these or other lophotrochozoans remains unknown. Here, we characterize m⁶A RNA regulation factors in the planarian Schmidtea mediterranea and analyze their function in development of the germline. Enriched expr

SUBMITTER: Tasaki J 

PROVIDER: S-EPMC12661160 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature