Unravelling the antibacterial performances of a homochiral d-configured tetraphenylalanine appended 16-HPA derivative based mechanoresponsive and proteolytically stable hydrogel.

ABSTRACT: Microbial infection is one of the most pressing global challenges worldwide, and imposes significant economic burdens on healthcare systems. This work represents a rational combinatorial strategy that leverages hydrophobic harmony in multiple phenylalanine fragments, anchored to an amphiphile 16-hydroxy-palmitic acid at the N-terminus (16-HPA-d-Phe-d-Phe-OH, compound I; 16-HPA-d-Phe-d-Phe-d-Phe-OH, compound II; 16-HPA-d-Phe-d-Phe-d-Phe-d-Phe-OH, compound III), such that a viable therapeutic skeleton could be uncovered through this strategy. In pursuit of this objective, the minimum inhibitory concentrations of compounds I-III were investigated using four distinct microorganisms namely Staphylococcus aureus and B. subtilis (Gram positive), and E. coli and P. aerugino

SUBMITTER: Shivhare V 

PROVIDER: S-EPMC12661181 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature