Contributions of the default mode and central executive networks during posterior cingulate cortex-targeted fMRI neurofeedback in PTSD.

ABSTRACT:

Introduction

Functional magnetic resonance imaging-based neurofeedback (fMRI-NFB) enables individuals to regulate brain activity implicated in psychopathology, including post-traumatic stress disorder (PTSD). While most fMRI-NFB studies in PTSD target the amygdala, which engages the central executive network (CEN) for top-down regulation, the posterior cingulate cortex (PCC), a core node of the default mode network (DMN), has recently emerged as a promising therapeutic target. However, the relative contributions of intra-network DMN mechanisms versus inter-network CEN engagement during PCC downregulation remain unclear.

Methods

We used independent component analysis (ICA) to examine DMN and CEN functional connectivity during PCC-targeted fMRI-NFB in individuals with PTSD (n 

SUBMITTER: Lieberman JM 

PROVIDER: S-EPMC12661201 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature