Glial cells missing 1 triggers gliosis and angiogenesis after neonatal brain injury.

ABSTRACT: The glial cells missing (Gcm) protein in Drosophila plays a crucial role in the cell fate switch in the nervous system and in induction of glial cell differentiation. However, the functions of the mammalian homolog Gcm1 in normal neural development and pathological conditions remain elusive. Here, we report that Gcm1 was upregulated in Nestin⁺ cells immediately after neonatal brain injury, followed by accumulation of GFAP⁺ and Olig2⁺ cells in the penumbra region. Injury-induced upregulation of Lif gene was mediated, at least in part, by the demethylation activity of Gcm1. In addition, Gcm1 strongly induced angiogenesis in the injury lesion as well as in the developing brain via vascular endothelial growth factor A and C activity. Lack o

SUBMITTER: Hayashi Y 

PROVIDER: S-EPMC12661203 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature