The gut microbiome associated with LGI1-antibody encephalitis.

ABSTRACT:

Objective

Autoimmune encephalitis is a cause of brain inflammation characterized by auto-antibodies, which target cell surface neuronal proteins and lead to neuronal dysfunction. The most common form is associated with auto-antibodies to leucine-rich glioma-inactivated 1 (LGI1) protein, the presentation of which includes frequent focal seizures. The exact cause of these auto-antibodies remains unknown, but established predispositions include overrepresented human leukocyte antigen (HLA) alleles. Yet, these HLA alleles are themselves common in the healthy ancestry-matched population. One potential etiological hypothesis is that an environmental trigger, such as the gut microbiome, interacts with a genetically predisposed individual.

Methods

To investigate this, we studied 42

SUBMITTER: Gilbert E 

PROVIDER: S-EPMC12661261 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature