Long-term survival after adult epilepsy surgery: Mortality and predictors in a large cohort.

ABSTRACT:

Objective

Long-term survival data in adults undergoing surgery for drug-resistant focal epilepsy remain limited. We examined mortality patterns and predictors in a large cohort followed for over 30 years.

Methods

Adults who underwent epilepsy surgery (1990-2022) were analyzed. Prospectively collected clinical, surgical, and outcome data were included. We estimated the cumulative incidence of mortality and standardized mortality ratios (SMRs) for the cohort. Predictors of epilepsy-related and non-epilepsy-related deaths were identified using Fine-Gray and cause-specific hazard models.

Results

A total of 1062 individuals contributed 14 279 person-years of follow-up (median, 13 years). The overall mortality rate was 6.16 per 1000 person-years, with 2.52 per 1000 person-y

SUBMITTER: Fiore G 

PROVIDER: S-EPMC12661268 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature