Motor-associated thalamic nuclei are reduced in juvenile myoclonic epilepsy.

ABSTRACT:

Objective

This study was undertaken to determine the thalamic nuclei that are different between juvenile myoclonic epilepsy (JME) and healthy controls from the Juvenile Myoclonic Epilepsy Connectome Project and then to determine their relationship with other subcortical gray matter volumes, disease covariates, and motor performance.

Methods

Sixty-two patients with JME and 41 age-matched controls (mean age = 20 years) were examined using T1-weighted images. Thalamic nuclei volumes were compared after normalization to total intracranial volume. The relationship between thalamic nuclei volumes and age, duration of epilepsy, number of antiseizure medications, and age at onset were examined using linear models with relative assessment of regressors. Correlation with other subcort

SUBMITTER: Struck AF 

PROVIDER: S-EPMC12661284 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature