Chronic behavioral and seizure outcomes following experimental traumatic brain injury and comorbid Klebsiella pneumoniae lung infection in mice.

ABSTRACT:

Objective

Traumatic brain injury (TBI) is a leading cause of long-term disability, and infections such as pneumonia represent a common and serious complication for patients with TBI in the acute and subacute post-injury period. Although the acute effects of infections have been documented, their long-term consequences on neurological and behavioral recovery as well as the potential precipitation of seizures after TBI remain unclear. This study aimed to investigate the chronic effects of Klebsiella pneumoniae infection following TBI, focusing on post-traumatic seizure development and neurobehavioral changes.

Methods

Using a mouse model, we assessed the long-term effects of TBI and K. pneumoniae infection both in isolation and in combination.

Results

We found that, alth

SUBMITTER: Rewell SSJ 

PROVIDER: S-EPMC12661288 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature