Green microwave synthesis of pyrazole chalcone molecular hybrids efficient route to advanced diabetes therapeutics with DNA intercalative properties.

ABSTRACT: Novel chalcone derivatives incorporating pyrazole moieties were synthesized via microwave assisted Claisen-Schmidt condensation and evaluated for their in vitro α-amylase and α-glucosidase inhibitory potential as therapeutic agents against diabetes mellitus, a rapidly escalating global health crisis. The microwave-assisted approach demonstrated remarkable synthetic advantages achieving excellent yields (80-85%) and enhanced product purity within minutes compared to conventional methods requiring over 24 hours. Five pyrazole-chalcone hybrids, L^I (C₁₉H₁₆N₂O), L^II (C₁₈H₁₄Cl₂N₂O), L^III (C₁₈H₁₄N₃O₃), L^IV (C₂₀

SUBMITTER: Sharma J 

PROVIDER: S-EPMC12661293 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature