Role of race and ethnicity in survival among children/young adults with relapsed ALL: a Children's Oncology Group report.

ABSTRACT:

Abstract

Pediatric Hispanic and Black patients with newly diagnosed B-cell acute lymphoblastic leukemia (B-ALL) experience worse overall survival (OS). We hypothesized that differential outcomes by race and ethnicity following relapse may contribute to disparities. We examined 2053 patients with ALL enrolled in frontline Children's Oncology Group trials from 1996 to 2014 who relapsed. We assessed the association of race and ethnicity, disease characteristics, and socioeconomic status with relapse survival predictors and postrelapse OS. For noninfant B-ALL, postrelapse OS (P = .002) and disease-related prognosticators such as time to relapse (P = .0002) differed by race and ethnicity. After adjusting for disease and patient characteristics, the OS association with overall race and e

SUBMITTER: Ligon JA 

PROVIDER: S-EPMC12661295 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature