The immune receptor FcRγ-chain mediates CD36-induced platelet activation and thrombosis by oxidized low-density lipoproteins.

ABSTRACT:

Abstract

The scavenger receptor CD36 links atherogenic dyslipidemia to platelet hyperactivity and accelerated thrombosis through the binding of oxidized low-density lipoproteins (oxLDL). The signaling mechanism(s) that facilitates CD36 translation of oxidative lipid stress into platelet activation is unclear. We examined the role of immunoreceptor tyrosine-based activation motif (ITAM) adapter proteins in CD36-mediated platelet activity. oxLDL induced the phosphorylation of the ITAM-containing adapter Fc receptor γ-chain (FcRγ) in human and murine platelets. Phosphorylation of FcRγ was blocked by Src family kinase (SFK) inhibitors, mimicked by CD36-specific oxidized phospholipids and ablated in CD36-/- murine platelets. Under basal conditions, a pool of CD36 formed a multiprotein c

SUBMITTER: Wraith KS 

PROVIDER: S-EPMC12661298 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature