Global trends, inequalities, and pathogen shifts in infectious diarrhea among children under five: a comprehensive analysis of the global burden of disease study 1990-2021.

ABSTRACT:

Background

Infectious diarrhea is a major cause of morbidity and mortality among children under five, particularly in low- and middle-income countries. Despite notable improvements in public health, substantial regional, national, and socioeconomic disparities persist, while the evolving pathogen spectrum presents new challenges for prevention and control.

Methods

We conducted a comprehensive analysis using data from the Global Burden of Disease (GBD) 2021 cycles, covering 204 countries and territories from 1990 to 2021. We assessed incidence, prevalence, mortality, and disability-adjusted life years (DALYs) at global, regional, national, and SDI quintile levels. Analytical methods included calculation of age-standardized rates (ASR), estimation of annual percentage changes

SUBMITTER: Tian Q 

PROVIDER: S-EPMC12661344 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature