Longitudinal alterations of gut microbiota associated with intrahepatic cholestasis of pregnancy: results from a large cohort study in China.

ABSTRACT:

Background

Intrahepatic cholestasis of pregnancy (ICP) is a significant pregnancy-specific hepatic disorder, yet the mechanisms linking the gut microbiota to ICP remain unclear.

Methods

Based on the Tongji-Huaxi-Shuangliu Birth Cohort, we included 4956 participants with repeated 16S rRNA sequencing data and clinical records in early, middle, and late pregnancy. We evaluated early pregnancy gut microbiota in relation to ICP risk, characterised longitudinal changes in women with and without ICP, and assessed hepatic markers as potential mediators.

Findings

Women with ICP exhibited different temporal changes in microbial diversity compared to non-ICP participants. Thirty-nine genera demonstrated significant associations with ICP in early pregnancy, and 9 genera showed co

SUBMITTER: Shan D 

PROVIDER: S-EPMC12661359 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature