One-pot CuI/l-proline-catalysed multicomponent synthesis of pyrido[2',1':2,3]imidazo[4,5-<i>c</i>]quinoline derivatives from 2-(2-bromophenyl)imidazo[1,2-<i>a</i>]pyridines, NH₃ and DMSO under air.

ABSTRACT: In a new approach, a series of pyrido[2',1':2,3]imidazo[4,5-c]quinoline (PIQ) derivatives were prepared in high yields from 2-(2-bromophenyl)imidazo[1,2-a]pyridines, NH₃ and DMSO via a tandem process including CuI/l-proline-catalysed C-N coupling and aerobic oxidative cyclization steps. Consequently, this method could be applied for the synthesis of a series of thiazolo[2',3':2,3]imidazo[4,5-c]quinolines and benzo[4',5']thiazolo[2',3':2,3]imidazo[4,5-c]quinolines in good yields via a similar approach.

SUBMITTER: Phuc BV 

PROVIDER: S-EPMC12661392 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature