PD-L1 and the risk of bacterial infection in patients with chronic liver diseases: An international multicohort study.

ABSTRACT:

Background & aims

Impaired phagocytic capacity due to activation of the PD-1/PD-L1 pathway has been implicated in the development of bacterial infections in patients with cirrhosis. Soluble PD-L1 (sPD-L1) is easily measurable in plasma and has been proposed as a biomarker of sepsis. In the current study, we aim to evaluate the role of sPD-L1 as a biomarker of bacterial infection development in patients with cirrhosis.

Methods

Plasma samples from 995 patients with chronic liver disease grouped in three cohorts were analyzed: an initial cohort of 268 hospitalized patients with acute decompensated cirrhosis, 327 out-patients with non-acute decompensated cirrhosis and finally 400 patients with high-risk alcohol consumption, including all stages of liver fibrosis, from mild/no fi

SUBMITTER: Juanola A 

PROVIDER: S-EPMC12661442 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature