Loss of O-GlcNAcylation in cardiac myocytes triggers the integrated stress response, contributing to heart failure.

ABSTRACT: Heart failure (HF) is a significant global health problem, affecting an estimated 64 million people worldwide. At the core of HF is the progressive dysfunction and irreversible loss of cardiac myocytes. O-GlcNAc transferase (OGT) is a conserved enzyme that catalyzes the addition of N-acetyl-glucosamine (GlcNAc) to serine or threonine residues of intracellular proteins. This dynamic protein modification, termed O-GlcNAcylation, has been implicated in nutrient sensing, metabolic regulation and stress adaptation. The integrated stress response (ISR) is a pathway that enables cells to rapidly respond to acute environmental changes and cell damage. During ISR, the translation factor eIF2α is phosphorylated, shutting down general translation but favoring the rapid production of stress-adaptive p

SUBMITTER: Papanicolaou KN 

PROVIDER: S-EPMC12661449 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature