Associations Between Ostomy Creation and Health-Related Quality of Life in Colorectal Cancer Patients: A Longitudinal Observational Study.

ABSTRACT:

Background

Many colorectal cancer (CRC) patients require stoma creation following surgical resection. Stomas can significantly impact health-related quality of life (HRQOL), yet prospective longitudinal studies exploring this are limited. This study aimed to assess HRQOL among CRC patients comparing between those with and without stomas, and examining differences between subgroups.

Methods

This prospective longitudinal study was conducted across five hospitals in Singapore from 2018 to 2023. CRC patients undergoing surgical resection were assessed at six timepoints from diagnosis to 12-month post-surgery. HRQOL was measured using the EORTC QLQ-C30 instrument. Multilevel mixed-effects tobit regression models were used to evaluate HRQOL changes over time and identify significa

SUBMITTER: Lau J 

PROVIDER: S-EPMC12661462 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature