Lymph Nodal Yield and Prediction of Mortality in Oral Squamous Cell Carcinoma Patients.

ABSTRACT:

Objective

Lymph nodal yield (LNY) is increasingly used in oral squamous cell carcinoma (OSCC) research as a prognostic factor and quality metric but remain to be validated across independent OSCC cohorts.

Study design

Retrospective cohort study.

Setting

Primary OSCC patients (n = 1080) who underwent a neck dissection, collected from three sites: Brescia, Cork, and Heidelberg.

Methods

The accuracy of LNY in predicting 3- and 5-year mortality was evaluated using the area under the ROC curve (AUC). Binomial regression models, adjusted for LNY and various confounders, were used to cross-validate predictive performance across independent cohorts. A model estimating the population-average treatment effect of LNY was used to estimate the effect of what would have been

SUBMITTER: Mirian C 

PROVIDER: S-EPMC12661473 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature