A review of metal ion complexation/decomplexation reaction-based fluorescent sensors for detecting biological thiols.

ABSTRACT: Biothiols such as glutathione (GSH), cysteine (Cys), and homocysteine (Hcy) are essential to many physiological and biochemical processes in humans, and their abnormal levels are associated with various health disorders. Fluorescent sensors based on metal ion complexation/decomplexation have emerged as powerful tools for the selective and sensitive detection of these thiols. This review highlights recent advances in biothiol sensing systems mediated by metal ions. Complexes of Cu²⁺ and Hg²⁺ have been most extensively investigated, while only limited studies involve ions such as Fe³⁺ and Ag⁺. The discussion emphasizes sensor mechanisms elucidated through analyses of reaction pathways, coordination chemistry, redox properties, stability constants,

SUBMITTER: Hien NK 

PROVIDER: S-EPMC12661497 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature