Characterization of genetic context of <i>bla</i> _KPC in <i>Pseudomonas aeruginosa</i>.

ABSTRACT: The rising prevalence of bla _KPC-harboring Pseudomonas aeruginosa (KPC-PA) is a significant threat to public health. In the study, we identified a carbapenem-resistant P. aeruginosa (CRPA; PAE3) from a patient with pneumonia infection. The resistance phenotype was analyzed using the broth microdilution method. Whole-genome sequencing was performed to sequence type (ST), resistance genes, plasmid replicon, and the genetic environment of the bla _KPC-2 gene. The other 75 Pseudomonas aeruginosa (PA) isolates with chromosome- or plasmid-borne bla _KPC gene were used to analyze the mobilized characterization of bla _KPC gene in PA from a global perspective. The result revealed PAE3 belonged to ST463 and ex

SUBMITTER: Chen M 

PROVIDER: S-EPMC12661517 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature