A scoping review on per- and poly-fluoroalkyl substances (PFAS) and colorectal cancer: Evidence from in vitro, animal, and epidemiological studies.

ABSTRACT:

Background and aims

Per- and poly-fluoroalkyl substances (PFAS) are persistent chemicals that contaminate air, water, soil, and food. Due to their widespread use, PFAS are detectable in most of the US population, raising concerns about potential health impacts, including a possible association with colorectal cancer (CRC). We conducted a scoping review of previously published studies to consolidate the current understanding of PFAS and its effect on CRC risk, identify knowledge gaps, and propose future directions for research.

Methods

We systematically searched PubMed, Scopus, and Web of Science for studies published through December 2024 that examined PFAS exposure in relation to CRC risk or progression. Data were independently extracted using a standardized protocol and st

SUBMITTER: Paudel D 

PROVIDER: S-EPMC12661558 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature