Spastic Ataxia Composite (SPAXCOM): A Scale to Evaluate the Progression of Subjects with Spasticity and Ataxia.

ABSTRACT:

Background

Current clinical scales that track disease progression are more tailored to spasticity or ataxia, with limited sensitivity to change.

Objectives

The aim was to develop a sensitive and valid scale specifically geared towards optimized sensitivity to change and adapted to patients presenting with both spasticity and ataxia.

Methods

Longitudinal data from 127 spastic paraplegia type 7 (SPG7) and 112 autosomal recessive spastic ataxia Charlevoix-Saguenay (ARSACS) patients were collected within the multicenter PROSPAX study. Sensitivity to change over 2 years of 30 items from the Scale for the Rating and Assessment of Ataxias (SARA), Spastic Paraplegia Rating Scale (SPRS), and the Activities of Daily Living subscale of the Friedreich's Ataxia Rating Scale (FARS-

SUBMITTER: Di Folco C 

PROVIDER: S-EPMC12661626 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature