Combined Dysfunction of the Amygdala and Nucleus Basalis Underlies Visual Hallucinations in Parkinson's Disease.

ABSTRACT:

Background

Visual hallucinations (VHs) are a common feature of Parkinson's disease (PD) believed to arise from disruptions to the functional architecture supporting sensory integration and attentional control. Across synucleinopathies, increased pathological burden in the amygdala and deficits in cholinergic modulation have been linked to VHs. However, the interaction of these changes and their combined contribution to the neurobiological mechanisms underlying hallucinatory phenomena remain poorly understood.

Objectives

To investigate the convergent impact of amygdala and cholinergic dysfunction on VHs in PD.

Methods

Seventy patients with PD, including 30 with and 40 without VHs, underwent structural and resting-state functional magnetic resonance imaging. Seed-based

SUBMITTER: Ignatavicius A 

PROVIDER: S-EPMC12661639 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature