Cerebellar organoids model cell type-specific FOXP2 expression during human cerebellar development.

ABSTRACT: Human cerebellar development is unique and cannot be fully replicated in animal models. Although human stem cell-derived cerebellar organoid models are increasingly being applied to model cerebellar diseases, their potential to provide insight into normal human cerebellar development remains underexplored. Here, we used CRISPR-based gene editing in cerebellar organoids as an approach for modelling specific features of early human cerebellar development. Forkhead box protein P2 (FOXP2) is a transcription factor associated with speech and language development that is highly expressed in the developing brain. However, little attention has been directed to the study of FOXP2 in the early developing cerebellum. We generated a fluorescent FOXP2 reporter line in human induced pluripotent stem cel

SUBMITTER: Apsley EJ 

PROVIDER: S-EPMC12661646 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature