Dataset Information
The beneficial effect of hepatic ER stress-associated protein PDI on obesity-associated glucose dysregulation.
Ontology highlight
ABSTRACT:
SUBMITTER: Fang D
PROVIDER: S-EPMC12661663 | biostudies-literature | 2025 Nov
REPOSITORIES: biostudies-literature
Publications
The beneficial effect of hepatic ER stress-associated protein PDI on obesity-associated glucose dysregulation.
Nutrition & metabolism 20251128 1
BACKGROUND: The liver plays critical roles in glucose metabolism regulation. Accumulating evidence supported that endoplasmic reticulum (ER) stress in liver tissue may involve in the development of type 2 diabetes. However, the role of ER stress-associated proteins in diabetes still needs to be clarified. METHODS: Genome-wide DNA methylome and proteome in the liver biopsies from patients with or without type 2 diabetes were performed and further validated by pyro-sequencing, real-time PCR and we ...[more]