Association of body roundness index with cardiovascular disease in early Cardiovascular-Kidney-Metabolic syndrome stage 0-3: mediation by the triglyceride-glucose index in a national cohort study.

ABSTRACT:

Background

Cardiovascular-Kidney-Metabolic (CKM) syndrome, encompassing metabolic dysfunction, chronic kidney disease, and cardiovascular disease (CVD), represents a growing global health challenge. Body Roundness Index (BRI) is an index representing viscera obesity, and its prospective association with CVD across CKM stages and mediation by insulin resistance remain unexamined.

Objective

The aim of the study was to explore the association between BRI and CVD among the population of CKM syndrome stage 0-3, and discover the potential mediation of insulin resistance.

Methods

This prospective cohort study included 7,214 participants from the China Health and Retirement Longitudinal Study (CHARLS). BRI was calculated using waist circumference and height. CKM stages (0-3)

SUBMITTER: Cai J 

PROVIDER: S-EPMC12661693 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature