Lactate alleviates intestinal barrier injury in weaned piglets via activation of the Wnt/β-catenin pathway and promotion of intestinal epithelial cell proliferation.

ABSTRACT:

Background

Inflammatory bowel disease causes intestinal structural damage, impairs gut function, hinders animal growth and development, and reduces farming efficiency. Previous studies demonstrated that lactate alleviates dextran sulfate sodium (DSS)-induced inflammation and mitigates weight loss by enhancing intestinal barrier functions. However, ‌the mechanisms underlying‌ lactate-mediated protection of the intestinal epithelial barrier ‌remain unclear‌. This study aimed to explore the protective effect of lactate on intestinal barrier damage in colitis piglets and the possible underlying mechanisms through in vivo and in vitro experiments.

Methods

A total of 60 21-day-old weaned female piglets were randomly assigned into three groups based on weight: the control group (ba

SUBMITTER: Wang M 

PROVIDER: S-EPMC12661717 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature