Quantitative proteomic analysis of pathological and physiological ovarian aging: model evaluation, molecular mechanisms, and identification of early biomarkers and therapeutic targets.

ABSTRACT:

Objectives

Ovarian aging is considered the "pacemaker" and "biological clock" of systemic female aging, with early manifestations that are often insidious. In this study, we analyzed the shared and distinct molecular signatures between physiological and pathological ovarian aging models using proteomic approaches, with the aim of identifying early predictive markers and therapeutic targets for ovarian aging, evaluating model fidelity, and elucidating underlying molecular mechanisms.

Methods

Ovarian tissue samples were collected from female C57/BL6 mice representing chemotherapeutic ovarian aging (8-week-old, Cyclophosphamide-Busulfan model) and natural ovarian aging (18-month-old). Initial validation of the models was conducted through histological assessment and serum hormo

SUBMITTER: Bai M 

PROVIDER: S-EPMC12661719 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature