Three-dimensional genome architecture connects chromatin structure and function in a major wheat pathogen.

ABSTRACT:

Background

Genome spatial organization plays a fundamental role in biological function across all domains of life. While the principles of nuclear architecture have been well-characterized in animals and plants, their functional relevance in filamentous fungi remains largely uncharacterized. The wheat pathogen Zymoseptoria tritici presents a unique model for genome evolution, with a compartmentalized genome comprising conserved core and highly variable accessory chromosomes linked to genome plasticity. Here, we present the first 3D genome analysis of a eukaryotic organism with an extensive set of accessory chromosomes, revealing a hierarchical genome architecture integrating core and accessory regions.

Results

At the nuclear level, centromere clustering defines the global ge

SUBMITTER: Glavincheska I 

PROVIDER: S-EPMC12661750 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature