Invasive Group A Streptococcus infections in children during the post-pandemic period: results from a multicenter study in Italy.

ABSTRACT:

Background

Group A Streptococcus causes pediatric infections from mild to severe forms. Since late 2022, invasive cases have increased in Europe, possibly due to reduced post-COVID-19 immunity, more respiratory virus circulation, and emergence of virulent strains.

Methods

A retrospective, multicenter observational study was conducted in twelve Italian pediatric Hospitals, including patients under 18 years hospitalized with invasive or severe Group A Streptococcus infection. Data were anonymized and analyzed to identify factors associated with Pediatric Intensive Care Unit (PICU) admission and discharge with sequelae or death.

Results

Seventy-five children with invasive or severe Group A Streptococcus infection were included; the majority (69.3%) were aged 2-10 years.

SUBMITTER: Chiappini E 

PROVIDER: S-EPMC12661756 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature