Bioinformatics analysis of Rickettsia typhi autoimmune associations and screening of Streptomyces-derived inhibitors.

ABSTRACT:

Background

Rickettsia typhi is the causative agent of epidemic murine typhus and Rocky Mountain spotted fever. The infection can affect multiple vital organs, including the heart, lungs, kidneys, and brain. Doxycycline is the recommended treatment but inflammation, mal-response, and drug resistance may arise. No natural product inhibitors have been reported against this bacterium.

Aim

The objective of this study was to establish a potential connection between autoimmune disorders triggered by R. typhi, identify therapeutic targets within its core proteome, and explore novel natural product inhibitors from Streptomyces spp. that could potentially inhibit it.

Methodology

Complete proteomes of four publicly available R. typhi strains were used for pan-proteomic analysis.

SUBMITTER: Basharat Z 

PROVIDER: S-EPMC12661794 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature