Reprogramming autoimmunity: inducing antigen-specific tolerance via apoptotic mimicry in an experimental model of multiple sclerosis.

ABSTRACT:

Background

Multiple sclerosis (MS) is an immune-mediated disorder characterized by demyelination, axonal damage, and neurodegeneration, leading to neurological disability in patients. It is considered a prototypic antigen-specific autoimmune disease, and therefore is a strong candidate for therapies aimed at restoring immune tolerance to self-antigens. However, the development of effective antigen-specific tolerization remains an important unmet medical need. In the present study, we administered phosphatidylserine (PS) liposomes, mimicking apoptotic bodies, containing a myelin antigen [35-55 myelin oligodendrocyte glycoprotein (MOG_35 - 55) peptide] in the MOG_35 - 55-induced experimental autoimmune encephalomyelitis (EAE), as a therapeutic strategy for the tre

SUBMITTER: Eixarch H 

PROVIDER: S-EPMC12661838 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature