The relationship between examined lymph nodes and oncological outcome of proximal gastrectomy for Siewert II/III adenocarcinoma of the esophagogastric junction.

ABSTRACT:

Objective

The objective of this study was to summarize the oncological outcomes and long-term prognosis of patients with Siewert II/III adenocarcinoma of the esophagogastric junction (AEG) who underwent proximal gastrectomy (PG) at the China National Cancer Center (CNCC), with particular focus on the relationship between the number of examined lymph nodes (ELNs) and prognosis.

Methods

We retrospectively analyzed 242 patients with Siewert II/III AEG who underwent PG between 2017 and 2021 at the CNCC. Lymphadenectomy followed D1 + principles for early-stage and D2 for advanced-stage disease. Recurrence-free survival (RFS) and overall survival (OS) were assessed using Kaplan-Meier curves, and prognostic factors were identified through Cox regression. Restricted cubic spline (RC

SUBMITTER: Wang H 

PROVIDER: S-EPMC12661840 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature