Identification of a novel diagnostic biomarker for osteoarthritis associated with chromatin regulators based on bioinformatics and experiments.

ABSTRACT:

Background

Osteoarthritis (OA) is a prevalent chronic degenerative joint disorder characterized by progressive cartilage degradation and extracellular matrix breakdown, yet its precise pathogenesis remains elusive. This study aimed to identify a novel diagnostic biomarker for OA associated with chromatin regulators (CRs) and to explore potential correlations between signature genes and immune cell infiltration.

Methods

OA datasets were retrieved from the Gene Expression Omnibus (GEO) database and integrated with a chromatin regulator (CR) dataset. Differential expression analysis was conducted to identify CR-related differentially expressed genes (DEGs), which were subsequently subjected to functional enrichment analysis. Hub genes associated with CRs were identified through

SUBMITTER: Wang X 

PROVIDER: S-EPMC12661842 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature