Cost-effectiveness of procalcitonin-guided antibiotic duration for hospitalized patients with sepsis.

ABSTRACT:

Background

Procalcitonin (PCT)-guided antibiotic duration for critically ill adults with sepsis may be clinically effective and safe. However, cost-effectiveness analyses using clinical trial data for this precision medicine approach in critical care are lacking. This economic evaluation investigates the cost-effectiveness of a daily PCT-guided protocol to guide the duration of antibiotic treatment in adult patients with sepsis.

Methods

Two analyses were conducted, the first estimating the cost per quality-adjusted life year (QALY) of the ADAPT-Sepsis study, which recruited 2760 patients randomized to a daily PCT-guided protocol, a daily C-reactive protein-guided protocol and standard care. The second analysis used meta-analyzed results from ADAPT-Sepsis and other PCT-guided

SUBMITTER: Stevenson M 

PROVIDER: S-EPMC12661845 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature