Immune imbalance mediates the relationship between plasma vitamin D concentration and preeclampsia in Chinese pregnant women: a case-control study.

ABSTRACT:

Background

Vitamin D insufficiency is associated with an increased risk of preeclampsia. However, the role of T helper cell type 1 (Th1)/Th2 and Th17/regulatory T cell (Treg) balance in this association is unclear.

Methods

We conducted a case-control study to explore the mediating effects of immune balance on the relationship between the plasma vitamin D concentration and preeclampsia. This study included 373 pregnant women recruited between March 2016 and February 2019 (192 cases and 181 controls). The cytokines as well as various T cell subsets were analyzed using ELISA and flow cytometry, respectively. Spearman's correlation was used to investigate the association between vitamin D and cytokines as well as T cell subsets and mediating analysis was performed to identify th

SUBMITTER: Chen H 

PROVIDER: S-EPMC12661851 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature