Doxorubicin-Cyclophosphamide Protocol in Dogs with Splenic Haemangiosarcoma and Haemoabdomen: A Retrospective Case Series.

ABSTRACT: This retrospective case series describes 21 dogs with stage II splenic haemangiosarcoma (HSA) and spontaneous haemoabdomen treated with splenectomy followed by a doxorubicin-cyclophosphamide protocol. Median overall survival was 92 days, with longer survival observed in dogs completing three or more chemotherapy cycles. The regimen was well tolerated, with low haematological and gastrointestinal toxicity. Maintenance metronomic chemotherapy was administered in a small subset, and it was associated with prolonged survival. While the sample size is modest, the homogeneous and clinically specific cohort provides hypothesis-generating observations on feasibility, tolerability, and time-aware associations that warrant cautious interpretation and prospective confirmation. No clinical or laborato

SUBMITTER: Del Castillo N 

PROVIDER: S-EPMC12661923 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature