Long-term follow-up study on the impact of a gut microbiota-supportive diet on heart failure and mortality outcomes.

ABSTRACT:

Background

Diet-driven modulation of gut microbiota may influence heart failure (HF) risk and mortality, but evidence in large populations is limited. We evaluated the association between a Dietary Index for Gut Microbiota (DI-GM) and prevalent HF.

Methods

DI-GM scores were derived from two 24-h dietary recalls. Logistic regression assessed odds of HF, diabetes, stroke, kidney failure, hypertension, and rheumatoid arthritis across DI-GM categories (1-3, 4, 5, ≥6), adjusting for demographics, lifestyle, BMI, and comorbidities. Restricted cubic splines examined dose-response. Mediation analysis quantified the roles of systemic immune-inflammation index (SII) and C-reactive protein (CRP). Kaplan-Meier and Cox models evaluated all-cause and cardiovascular mortality by DI-GM (>4

SUBMITTER: Xu M 

PROVIDER: S-EPMC12661986 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature