Cell-penetrating peptide-functionalized biomimetic nanovesicles for efficient cataract treatment via enhanced corneal penetration and lens-mitochondria dual targeting.

ABSTRACT: Cataract is the leading cause of blindness worldwide. While the oxidative stress homeostasis unbalance of the lens is a key pathological mechanism underlying cataract formation. Due to the lens being deeply embedded behind multiple biological barriers, there is no effective drug treatment for cataract currently. In this study, a multifunctional nanodelivery system (LSPE@Cur) was designed based on cell-penetrating peptide (PENE)-functionalized biomimetic membrane hybrid technology, which prevents cataract by collaboratively regulating mitochondrial homeostasis and oxidative stress balance. The system was constructed by curcumin (Cur)-lipid encapsulation technology combined with PENE functionalization, followed by exosome membrane fusion, creating a biomimetic nanocarrier with long ocular su

SUBMITTER: Zhang R 

PROVIDER: S-EPMC12661988 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature