Buprenorphine Treatment Duration and Adherence Among Youth and Subsequent Health Outcomes.

ABSTRACT:

Objectives

It is unclear how long youth with opioid use disorder (OUD) should continue taking buprenorphine, and what adherence they should achieve. We identified patterns of duration/adherence and assessed associations with subsequent overdose, emergency department (ED) use, and hospitalization.

Methods

This retrospective cohort analysis used 2014-2022 data from the Massachusetts Public Health Data Warehouse. We identified youth aged 13 to 26 years initiating buprenorphine and used group-based trajectory modeling to categorize youth into duration/adherence trajectories over 12 months. Using multivariable Cox regression, we examined associations between trajectories and time to fatal/nonfatal opioid overdose, all-cause ED use, and all-cause hospitalization during the subsequ

SUBMITTER: Hadland SE 

PROVIDER: S-EPMC12662019 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature