A Randomized Controlled Trial of a Partially Hydrolyzed Formula on Comfort Measures in Fussy Infants.

ABSTRACT:

Background

Parent-reported fussiness and crying are common during early infancy and may be alleviated by switching the formula for infants who are formula fed.

Objectives

This study evaluated the nutritive effects of a partially hydrolyzed cow milk protein (PHP) formula with an added prebiotic blend on parent/caregiver-reported fussiness and other measures of comfort in infants with perceived fussiness.

Methods

Infants (15-75 d of age) exclusively receiving a commercial intact protein infant formula and rated moderately, very, or extremely fussy were randomized to receive intact cow milk protein formula (control, n = 73) or investigational PHP formula (INV-PHP, n = 76). Both formulas had a prebiotic blend of polydextrose and galactooligosaccharides (1:1,

SUBMITTER: Fabrizio V 

PROVIDER: S-EPMC12662101 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature